RAW Ketamine 500 Grams
What is Ketamine?
Ketamine is a medication primarily used for starting and maintaining anesthesia. It induces dissociative anesthesia, a trance-like state providing pain relief, sedation, and amnesia. The distinguishing features of ketamine anesthesia are preserved breathing and airway reflexes stimulated heart function with increased blood pressure and moderate bronchodilation. At lower, sub-anesthetic doses, ketamine is a promising agent for pain and treatment-resistant depression. However, the antidepressant action of a single administration of ketamine wanes with time, and the effects of repeated use have not been sufficiently studied.
What is the dosage of Ketamine?
- Most people snort small lines or “bumps” of about 30-60 milligrams, and the effect comes on within about 5 to 15 minutes. (Onset can be much longer if swallowed.)
- 100mg is usually enough to enter a full dissociative state (a.k.a, “k-hole”).
- If liquid ketamine is injected, less is needed to enter a k-hole, and the effects can be felt within minutes. It is much more common to inject ketamine intramuscularly than intravenously in recreational settings, but ketamine will be administered through an IV drip in a clinical setting.
Dosage Forms & Strengths
injectable solution: Schedule III
- 10mg/mL
- 50mg/mL
- 100mg/mL
Anesthesia Induction
Load
- IV: 1-4.5 mg/kg slow IV once
- Alternatively (off-label): 0.5-2 mg/kg slow IV if adjuvant drugs (eg, midazolam) are used, OR
- IM: 6.5-13 mg/kg IM once
- Alternatively (off-label): 4-10 mg/kg IM once if adjuvant drugs (eg, midazolam) are used
Maintenance
- 50% of IV ketamine induction dose administered PRN, OR
- 0.1-0.5 mg/min IV continuous infusion
Resistant Depression (Off-label)
Infusion: 0.5 mg/kg IV twice weekly; not to exceed 6 weeks; therapy >6 weeks not studied